腸道巨噬細(xì)胞代表了多種的常駐組織巨噬細(xì)胞來(lái)源 [1, 2]。腸道常駐巨噬細(xì)胞是一種重要的免疫群體簡單化，能夠在其環(huán)境中整合和解釋不同的食物來(lái)源、共生來(lái)源敢於挑戰、病原體來(lái)源和宿主來(lái)源的信號(hào)。此外建立和完善，在炎癥反應(yīng)下提供了遵循，BM 衍生的腸道巨噬細(xì)胞和常駐巨噬細(xì)胞在控制感染中起關(guān)鍵作用。因此大型，腸道巨噬細(xì)胞池的動(dòng)態(tài)調(diào)節(jié)是長(zhǎng)期健康的核心[3]服務效率。補(bǔ)充健康腸道中常駐池的 BM 衍生巨噬細(xì)胞被確定為 CX3CR1hiMHCIIhiLy6Clow [103]明確相關要求，它們?cè)谀c道穩(wěn)態(tài)中具有多種關(guān)鍵功能，包括 Treg 擴(kuò)增統籌發展、上皮維持深化涉外、管腔取樣和細(xì)菌殺滅 [4, 5]。如表 4 所示生產製造，腸道和真皮被認(rèn)為是開放組織開展試點，具有快速募集和分化骨髓來(lái)源的單核細(xì)胞成巨噬細(xì)胞的動(dòng)力學(xué)。盡管在出生時(shí)是目前主流，腸道中存在胚胎衍生的巨噬細(xì)胞研究，但這些巨噬細(xì)胞被來(lái)自大量 CCR2 依賴性 Ly6Chi 單核細(xì)胞的細(xì)胞所取代[6]。巨噬細(xì)胞上的 IL-10 受體信號(hào)傳導(dǎo)是一種對(duì)指導(dǎo)胃腸粘膜中巨噬細(xì)胞功能至關(guān)重要的途徑 [7, 8]應用創新。
如何研究腸道巨噬細(xì)胞的功能？一個(gè)強(qiáng)有力的工具就是清除腸道巨噬細(xì)胞機構。靶點(diǎn)科技庫(kù)存大量LIPOSOMA的ClodronateLiposomes氯膦酸二鈉脂質(zhì)體的特性。作為授權(quán)的中國(guó)Exclusive Distributor，無(wú)論從產(chǎn)品質(zhì)量還是技術(shù)支持基礎，都能給予從理論到實(shí)踐的賦能提供堅實支撐。
參考文獻(xiàn)
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6. Smythies L, Sellers M, Clements R, Mosteller Barnum M, Meng G, Benjamin W, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Invest. 2005;115:66-75
7. Bain C, Bravo Blas A, Scott C, Perdiguero E, Geissmann F, Henri S, et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat Immunol. 2014;15:929-937
8. Shouval D, Biswas A, Goettel J, McCann K, Conaway E, Redhu N, et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014;40:706-19
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